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Daak, Ahmed A., Ghebremeskel, Kebreab, Hassan, Zahir, Attallah, Bakhita, Azan, Haj H., Elbashir, Mustafa I. and Crawford, Michael A. (2013) Reply to UN Das. The American Journal of Clinical Nutrition, 97 (6). pp. 1416-1417. ISSN 0002-9165
We thank Das for his interest in our article (1) and for proposing a possible mechanism for the efficacy of omega-3 (n–3) fatty acid in ameliorating vaso-occlusive crisis and hemolytic events in homozygous sickle cell patients.
The purpose of our randomized placebo-controlled trial was to investigate efficacy and safety and not to elucidate mechanisms underlying the beneficial effects of omega-3 fatty acids. Nevertheless, the points raised by Das are worth discussing because of their relevance for future mechanistic studies.
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