Preliminary design for reference tracking feedback for medical cyber-physical pharmacokinetic systems

Oliveira, Pedro M., Bustos, Daniel, Lobo, Rodolfo, Lacerda, Marcio J. and Palma, Jonathan M. (2024) Preliminary design for reference tracking feedback for medical cyber-physical pharmacokinetic systems. In: 2024 IEEE International Conference on Automation/XXVI Congress of the Chilean Association of Automatic Control (ICA-ACCA), 20-23 October 2024, Santiago, Chile.

Abstract

This paper addresses the reference tracking control problem for Medical Cyber-Physical Systems (MCPS). The control theory is employed to guarantee the suitable concentration of drugs in the body of patients to guarantee a safe treatment. The MCPS is modeled as a switched system, and the modes consider the different scenarios for the problem. A discrete-time model is utilized for the pharmacokinetic process, and the zero input control strategy is employed to design state-feedback controllers with a guaranteed exponential convergence rate. A numerical experiment is presented to illustrate the validity and effectiveness of our method.

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