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Lange, Sigrun and Inal, Jameel (2024) Animal models of human disease 2.0. International Journal of Molecular Sciences, 25(24) (13743). pp. 1-9. ISSN 1422-0067
The use of animal models is crucial for advancing translational research by identifying effective treatment targets and strategies for clinical application in human disease. This Special Topic "Animal Models of Human Disease 2.0", called for state-of-the-art primary research and review articles, inviting global experts conducting fundamental and translational research in comparative animal models of human diseases. Submissions were invited on topics related to chronic pathologies, including autoimmune and neurodegenerative diseases, cancer, acute injury, inflammatory and infectious diseases, and regenerative medicine. The five participating MDPI journals were Biomedicines, Cells, Current Issues in Molecular Biology, Genes, and the International Journal of Molecular Sciences. A total of twenty-two papers were published, including two comprehensive reviews on the use of diverse animal models to advance translational research and twenty original research papers using more common and conventional laboratory animal models (mice, rats, rabbits) or other less frequent comparative models (dogs and plateau pikas). Findings reported in this Special Topic provide significant new information on fundamental pathobiological mechanisms and clinical markers of chronic and acute human pathologies and investigate exposome effects on human health. Research topics included nervous system, liver, lung, and cardiac diseases, the gut microbiome, host–pathogen interactions, antibiotic resistance, pathological effects and/or therapeutic potential of selected drugs and compounds, mitochondrial-mediated mechanisms, and hypoxia-mediated pathways. Topics of regenerative medicine discussed the use of stem cells and gene-edited animal models. Research on exposome-related factors included blue light irradiation and microgravity, highlighting risks to human health regarding the overuse of smart digital devices and future long-term spaceflight missions.
Available under License Creative Commons Attribution 4.0.
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