Amyloidosis: perspectives and recent advances

Terry, Cassandra (2022) Amyloidosis: perspectives and recent advances. Life (Basel, Switzerland). ISSN 2075-1729

Abstract

The ability of proteins to change their secondary structure and form insoluble fibrous material named amyloid in a process called amyloidosis (or protein misfolding) is the focus of this Special Issue. In this Special Issue edited by Dr Cassandra Terry, we welcome research papers and review articles that explore the phenomenon of amyloidosis and the consequences of this in biology. We welcome papers that address the roles of amyloidogenic proteins in disease and normal physiology and papers that evaluate the interaction between these different amyloidogenic proteins. Related to disease, these could include (but are not limited to) how amyloidosis is associated with neurodegenerative diseases such as Alzheimer’s disease and prion disorders or how amyloidosis affects other parts of the body such as in diabetes or cataract formation. We also welcome papers that discuss important functional amyloids such as amyloid proteins from prokaryotes (bacteria) and eukaryotes (fungi, insects, invertebrates, and humans). Importantly, we are also interested in papers that investigate recent advances in determining structures of amyloidogenic proteins and the impact this has had on understanding disease and developing therapeutics. This could include the challenges involved in developing treatments against amyloid disorders plus advances in state-of-the-art techniques being utilised for drug discovery and therapeutic development.

This Special Edition, guest edited by Cassandra Terry, aims to highlight the importance of amyloidosis research to give the reader a comprehensive overview outlining recent developments in research and clinical applications from different perspectives.

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