Dear Colleagues,

The ability of proteins to change their secondary structure and form insoluble fibrous material named amyloid in a process called amyloidosis (or protein misfolding) is the focus of this Special Issue. In this Special Issue edited by Dr Cassandra Terry, we welcome research papers and review articles that explore the phenomenon of amyloidosis and the consequences of this in biology. We welcome papers that address the roles of amyloidogenic proteins in disease and normal physiology and papers that evaluate the interaction between these different amyloidogenic proteins. Related to disease, these could include (but are not limited to) how amyloidosis is associated with neurodegenerative diseases such as Alzheimer’s disease and prion disorders or how amyloidosis affects other parts of the body such as in diabetes or cataract formation. We also welcome papers that discuss important functional amyloids such as amyloid proteins from prokaryotes (bacteria) and eukaryotes (fungi, insects, invertebrates, and humans). Importantly, we are also interested in papers that investigate recent advances in determining structures of amyloidogenic proteins and the impact this has had on understanding disease and developing therapeutics. This could include the challenges involved in developing treatments against amyloid disorders plus advances in state-of-the-art techniques being utilised for drug discovery and therapeutic development.

This Special Edition aims to highlight the importance of amyloidosis research to give the reader a comprehensive overview outlining recent developments in research and clinical applications from different perspectives.

This Special Issue is now open for submissions. Prospective authors should first send a short abstract or tentative title to the Editorial Office. If the editors deem the topic to be appropriate for inclusion in this Special Issue, the author will be encouraged to submit a full manuscript.

Dr. Cassandra Terry
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• amyloid
• protein misfolding 
• neurodegenerative disease
• protein structure
• aggregation
• therapeutics