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Kidd, Elliot, Meimaridou, Eirini, Walley, Andrew and Fairbrother, Una (2023) Telomere oxidation status (TOS) is correlated with relative telomere length (RTL) across different mouse tissues but not with nicotinamide nucleotide transhydrogenase (Nnt) status. In: ESHG 2023 - 56th European Society of Human Genetics Conference, 10-13th June 2023, Glasgow.
We demonstrate that tissues with the shortest TL, showed the highest TOS and tissues with the longest TL, the lowest TOS. Surprisingly, murine Nnt status is not associated with TL or TOS. Background Numerous studies imply that oxidative stress is associated with TL but rarely directly assay oxidative damage in telomeric DNA. We used a mouse model to demonstrate telomere specific oxidative stress and its effects on TL, in a range of tissues. These mice have a naturally occurring Nnt deficiency. Previous reports suggest that absence of Nnt results in high levels of cellular reactive oxygen species (ROS). We investigated whether Nnt deficient mice have reduced TL and display markers of TOS compared to WT and rescued mice and whether this was tissue specific.
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