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The novel BRDT inhibitor NHWD870 shows potential as a male contraceptive in mice

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Wu, Sixian, Li, Xiaoliang, Shang, Lijun, Wu, Lvying, Li, Tongtong, Li, Peiyv, Ji, Zhiliang, Hou, Jianwen, Yin, Mingzhu and Xu, Wenming (2022) The novel BRDT inhibitor NHWD870 shows potential as a male contraceptive in mice. Acta Biochimica et Biophysica Sinica, 54 (10). pp. 1-12. ISSN 1745-7270

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Abstract

Small molecule inhibitors of the bromodomain and extraterminal domain (BET) family proteins have emerged as a promising option for not only the treatment of multiple cancers but also for disturbing the process of sperm maturation with potential for use as a viable contraceptive target. In this paper, we report a new generation of BET family inhibitor, NHWD870, that provide a complete and reversible contraceptive effect in mice which is stronger than that of JQ1 and its synthesized derivatives. This study is hoped to lead to the clinical trial eventually.

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