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Kempf, Kerstin, Röhling, Martin, Banzer, Winfried, Braumann, Klaus-Michael, Halle, Martin, Schaller, Nina, McCarthy, H. David, Predel, Hans-Georg, Schenkenberger, Isabelle, Tan, Susanne, Toplak, Hermann, Martin, Stephan and Berg, Aloys (2022) High-protein, low-glycaemic meal replacement improves physical health-related quality of life in high-risk persons for metabolic syndrome—a subanalysis of the randomised-controlled ACOORH trial. Nutrients, 14 (15). pp. 1-12. ISSN 2072-6643
While obesity impairs health-related quality of life (HRQOL), lifestyle interventions targeting weight reduction have been effective in improving HRQOL. Therefore, we hypothesised that a meal replacement-based lifestyle intervention, which has been shown to successfully reduce weight, would also improve HRQOL more effectively than a lifestyle intervention alone. In the international, multicenter, randomised-controlled ACOORH-trial (Almased-Concept-against- Overweight-and-Obesity-and-Related-Health-Risk), overweight or obese participants with elevated risk for metabolic syndrome (n = 463) were randomised into two groups. Both groups received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement for 6 months. HRQOL was estimated at baseline, after 3 and 12 months, using the SF-36 questionnaire, and all datasets providing HRQOL data (n = 263) were included in this predefined subanalysis. Stronger improvements in the physical component summary (PCS) were observed in the intervention compared to the control group, peaking after 3 months (estimated treatment difference 2.7 [1.2; 4.2]; p 0.0001), but also in the long-term. Multiple regression analysis demonstrated that insulin levels and the achieved weight loss were associated with the mental component summary (MCS) after 12 months (p 0.05). Thus, meal replacement-based lifestyle intervention is not only effective in weight reduction but, concomitantly, in enhancing HRQOL.
Available under License Creative Commons Attribution 4.0.
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