Linking hIAPP misfolding and aggregation with type 2 diabetes mellitus: a structural perspective

Hassan, Shahab, White, Kenneth and Terry, Cassandra (2022) Linking hIAPP misfolding and aggregation with type 2 diabetes mellitus: a structural perspective. Bioscience reports, 42 (5). pp. 1-24. ISSN 1573-4935

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Abstract / Description

There are over 40 identified human disorders that involve certain proteins folding incorrectly, accumulating in the body causing damage to cells and organs and causing disease. Type 2 Diabetes Mellitus is one of these protein misfolding disorders and involves human islet amyloid polypeptide misfolding and accumulating in parts of the body, primarily in the pancreas causing damage to islet cells and affecting glucose regulation. In this review, we have summarised our current understanding of what causes hIAPP to misfold, what conformations are found in different parts of the body with a particular focus on what is known about the structure of hIAPP and how this links to Type 2 Diabetes Mellitus. Understanding the molecular basis behind these misfolding events is essential for understanding the role of hIAPP to develop better therapeutics since type 2 diabetes currently affects over 4.9 million people in the UK alone and is predicted to increase as our population ages.

Item Type: Article
Additional Information: [Abstract copyright: Copyright 2022 The Author(s).]
Uncontrolled Keywords: diabetes; amyloid; hIAPP; pancreas; Islets of Langerhans; animals; humans, diabetes mellitus; type 2; protein folding; islet amyloid polypeptide
Subjects: 600 Technology > 610 Medicine & health
Department: School of Human Sciences
Depositing User: Cassandra Terry
Date Deposited: 16 May 2022 15:03
Last Modified: 24 Jun 2022 13:38


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