Lists
Lists
Khalili, Leila, Valdes-Ramos, Roxana and Harbige, Laurence S. (2021) Effect of n-3 (Omega-3) polyunsaturated fatty acid supplementation on metabolic and inflammatory biomarkers and body weight in patients with Type 2 Diabetes Mellitus: a systematic review and meta-analysis of RCTs. Metabolites, 11 (742). pp. 1-21. ISSN 2218-1989
|
Text
metabolites-11-00742.pdf - Published Version Available under License Creative Commons Attribution 4.0. Download (1MB) | Preview |
Abstract / Description
Beneficial effects of n-3 fatty acids on metabolic biomarkers in patients with type 2 diabetes (T2DM) has been reported. The objectives of this current research were to investigate the effects of n-3 supplementation on metabolic factors, weight, and body mass index (BMI) in patients with type 2 diabetes mellitus (T2DM), using a meta-analysis of randomized, controlled trials (RCTs). Online databases PubMed, Embase, Web of Science, and Science Direct were searched until 2021 to identify eligible articles. Thirty-two trials were included. The results showed that n-3 consumption can significantly reduce glycemic factors including fasting blood sugar (FBS) (−0.36 (−0.71 to −0.01)), glycated hemoglobulin (HbA1c) (−0.74 (−1.13 to −0.35)), and homeostatic model assessment of insulin resistance (HOMA.IR) (−0.58 (−1.13 to −0.03)). Furthermore, significant improvement in lipid profile including triglycerides (TG) (−0.27 (−0.37 to −0.18)), total cholesterol (−0.60 (−0.88 to −0.32)), low density lipoprotein (LDL) (−0.54 (−0.85 to −0.23)), and high-density lipoprotein (HDL) (0.60 (0.23 to 0.96)) levels were found in the present meta-analysis. The reduction in the inflammatory marker’s tumor necrosis factor-alpha (TNF-α) (−0.13 (−0.75 to 0.48)) and c-reactive protein (CRP) (−0.72 (−1.70 to 0.27)), as well as weight (−0.09 (−0.24 to 0.07)) and BMI (−0.13 (−0.29 to 0.02)) were not statistically significant. Furthermore, the findings revealed that the optimal dose and duration of n-3 consumption for patients with T2DM is 1000–2000 mg/d for more than 8 weeks. The present meta-analysis and review reveals that n-3 supplementation can improve glycemic factors and lipid profile in patients with T2DM. Furthermore, n-3 supplementation may provide beneficial effects on inflammatory markers and body weight if used at the appropriate dose and duration.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | meta‐analysis; n‐3; polyunsaturated fatty acids PUFA; T2DM; diabetes; randomized; controlled trials RCTs; glycemic control; metabolic and inflammatory biomarkers; weight; BMI |
| Subjects: | 600 Technology > 610 Medicine & health |
| Department: | School of Human Sciences |
| SWORD Depositor: | Pub Router |
| Depositing User: | Pub Router |
| Date Deposited: | 05 Nov 2021 15:23 |
| Last Modified: | 06 Mar 2023 14:38 |
| URI: | https://repository.londonmet.ac.uk/id/eprint/7087 |
Downloads
Downloads per month over past year
Downloads each year
Actions (login required)
 |
View Item |