Exploring the potential of the recombinant human collagens for biomedical and clinical: a short review

Chen, Zhuoyue, Fan, Daidi and Shang, Lijun (2021) Exploring the potential of the recombinant human collagens for biomedical and clinical: a short review. Biomedical materials, 16 (1). ISSN 1748-6041

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Abstract / Description

Natural animal collagen and its recombinant collagen are favorable replacements in human tissue engineering due to their remarkable biomedical property. However, this exploitation is largely restricted due to the potential of immunogenicity and virus contamination. Exploring new ways to produce human collagen is a fundamental key to its biomedical and clinical application. All human fibrillar collagen molecules have three polypeptide chains constructed from a repeating Gly-Xaa-Yaa triplet, where Xaa and Yaa represent one random amino acid. Using cDNA techniques to modify several repeat sequences of the cDNA fragment, a novel human collagen named recombinant human-like collagen (HLC), with low immunogenicity and little risk from hidden virus can be engineered and notably tailored to specific applications. HLC was initially used as a coating to modify the tissue engineering scaffold, and then used as the scaffold after cross link agents were added to increase its mechanical strength. Due to its good biocompatibility, low immunogenicity, stabilised property and the ability of mass production, HLC has been widely considered to use in skin injury treatments, vascular scaffolds engineering, cartilage, bone defect repair, skincare, haemostatic sponge, and drug delivery including coating with medical nanoparticles. In this review, we symmetrically reviewed the development, recent advances in design and application of HLC, and other recombinant human collagen-based biomedicine potentials. For comparison and providing basic background information about the techniques, we start with recombinant human collagens. In the end, future improvements in using HLC are also discussed.

Item Type:	Article
Uncontrolled Keywords:	recombinant human collagen; human-like collagen (HLC); tissue engineering; drug delivery; medical nanoparticle
Subjects:	500 Natural Sciences and Mathematics > 540 Chemistry & allied sciences 500 Natural Sciences and Mathematics > 570 Life sciences; biology
Department:	School of Human Sciences
Depositing User:	Lijun Shang
Date Deposited:	24 Nov 2020 13:40
Last Modified:	07 Dec 2022 12:30
URI:	https://repository.londonmet.ac.uk/id/eprint/6191

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