Alcohol consumption and all-cause mortality: an analysis of general practice database records for patients with long-term conditions

Stewart, Duncan, Han, Lu, Doran, Tim and McCambridge, Jim (2017) Alcohol consumption and all-cause mortality: an analysis of general practice database records for patients with long-term conditions. Journal of Epidemiology and Community Health, 71 (8). pp. 729-735. ISSN 0143-005X

CPRD_final_accepted_version.JECH.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial 4.0.

Download (217kB) | Preview
Official URL:

Abstract / Description

Alcohol is a risk factor for ill health and reduced life expectancy, but little is known about the impact of alcohol on mortality for people with existing long-term conditions. We used primary care data from the Clinical Practice Research Datalink (CPRD) to study relationships between alcohol consumption and all-cause mortality among general practice patients with long-term conditions.

Data were accessed from a sample of 125 general practices from the CPRD database. Adult patients with long-term health conditions, a record of alcohol consumption in CPRD and at least 1 year of follow-up data between 2000 and 2014 (n=95 991) were matched to the Office for National Statistics (ONS) mortality register.

In Cox proportional hazards regression models, mortality was higher for patients consuming 25-34 units of alcohol per week (HR 1.26, 95% CI 1.12 to 1.42) and 35 units or more (HR 1.71, 95% CI 1.51 to 1.94), compared with those drinking 1-7 units per week. Patterns of mortality risk were the same for men and women. Heavy drinking increased mortality risk in combination with smoking (HR 4.04, 95% CI 3.41 to 4.79) and high levels of deprivation (HR 3.01, 95% CI 2.40 to 3.79).

Heavier drinkers with long-term conditions are at significantly greater risk of death than lighter drinkers. The findings support the UK Chief Medical Officers' guidance on having similar low-risk alcohol consumption guidelines for men and women. More needs to be done to tackle alcohol consumption among patients with long-term conditions.

Item Type: Article
Uncontrolled Keywords: alcohol consumption; all-cause mortality; people with existing long-term conditions
Subjects: 600 Technology > 610 Medicine & health
Department: School of Social Professions (to June 2021)
School of Social Sciences and Professions
Depositing User: Duncan Stewart
Date Deposited: 13 Aug 2020 08:26
Last Modified: 13 Aug 2020 08:26


Downloads per month over past year

Downloads each year

Actions (login required)

View Item View Item