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Inal, Jameel (2020) COVID‐19 comorbidities, associated procoagulant extracellular vesicles and venous thromboembolisms: a possible link with ethnicity? British Journal of Haematology, 190 (4). ISSN 1365-2141
In view of numerous recent reports describing increased risks of thrombosis in coronavirus disease 2019 (COVID-19) amongst certain ethnicities in which co-morbidities are more prevalent, besides the identified risk factors, procoagulant plasma extracellular vesicles have not been considered. Several comorbidities predict mortality in patients with COVID19, some of which are more prevalent in Black, Asian and Minority Ethnic (BAME) groups. In a meta-analysis of seven studies (1,576 infected patients) the co-morbidities included hypertension (21.1%), diabetes (9.7%), cardiovascular disease (CVD), (8.4%) and respiratory system disease (1.5%). Of the critically ill COVID-19 patients with these co-morbidities and an associated hyperinflammatory state admitted to intensive care units (ICUs), up to 31% suffered thrombotic episodes (even with thromboprophylaxis), in particular, venous thromboembolisms (VTE), one of the important sequelae of COVID-19.
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