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Use of LC-MS analysis to elucidate by-products of niacinamide transformation following in vitro skin permeation studies

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Sil dos Santos, Bruno and Moore, David J. (2018) Use of LC-MS analysis to elucidate by-products of niacinamide transformation following in vitro skin permeation studies. International journal of cosmetic science, 40 (5). pp. 525-529. ISSN 1468-2494

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Abstract

Pyridine-3-carboxamide, also known as niacinamide (NIA), is used in many pharmaceutical and personal care formulations for the improvement of skin barrier function, management of acne and amelioration of the symptoms of atopic dermatitis [1-3]. The widespread use of NIA (Table I) in skin care highlights the importance of understanding the percutaneous penetration and skin distribution of this molecule [4]. Previously, we have conducted several studies that have evaluated a wide variety of NIA formulations [4, 5].

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