3D‐printed polypropylene continuous‐flow column reactors: exploration of reactor utility in SNAr reactions and the synthesis of bicyclic and tetracyclic heterocycles

Rao, Zenobia X., Patel, Bhaven, Monaco, Alessandra, Cao, Zi Jing, Barniol-Xicota, Marta, Pichon, Enora, Ladlow, Mark and Hilton, Stephen T. (2017) 3D‐printed polypropylene continuous‐flow column reactors: exploration of reactor utility in SNAr reactions and the synthesis of bicyclic and tetracyclic heterocycles. European Journal of Organic Chemistry, 2017 (44). pp. 6499-6504. ISSN 1434-193X

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Abstract / Description

3D printing has the potential to transform the way in which chemical reactions are carried out due to its low‐cost, ease‐of‐use as a technology and its capacity to expedite the development of iteratively enhanced prototypes. In this present study, we developed a novel, low‐cost polypropylene (PP) column reactor that was incorporated into an existing continuous‐flow reactor for the synthesis of heterocycles. The utility and solvent resistance of the printed devices were explored in SNAr reactions to produce substituted aniline derivatives and in the synthesis of bicyclic and tetracyclic heterocycles. Using this approach, a range of heterocyclic compounds was synthesised including the core structure of the natural product (±)‐γ‐lycorane and structurally complex compounds based on the tetracyclic core of the erythrina alkaloids.

Item Type:	Article
Additional Information:	"This is the peer reviewed version of the following article: Rao, Z.X., Patel, B., Monaco, A., Cao, Z.J., Barniol-Xicota, M., Pichon, E., Ladlow, M. and Hilton, S.T. (2017), 3D-Printed Polypropylene Continuous-Flow Column Reactors: Exploration of Reactor Utility in SNAr Reactions and the Synthesis of Bicyclic and Tetracyclic Heterocycles. Eur. J. Org. Chem., 2017: 6499-6504, which has been published in final form at https://doi.org/10.1002/ejoc.201701111. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."
Uncontrolled Keywords:	3D-printing; Synthetic methods; Heterocycles; Nucleophilic substitution
Subjects:	500 Natural Sciences and Mathematics > 540 Chemistry & allied sciences
Department:	School of Human Sciences
Depositing User:	Bhaven Patel
Date Deposited:	21 Oct 2022 09:15
Last Modified:	21 Oct 2022 09:15
URI:	https://repository.londonmet.ac.uk/id/eprint/1405

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