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Therapeutic potential of goldenseal root extract on glucose metabolism and weight reduction in diabetic rats

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Kandunuri, Kiran Kumar, White, Kenneth and Gajula, Rajesh Goud (2025) Therapeutic potential of goldenseal root extract on glucose metabolism and weight reduction in diabetic rats. Journal of Medicinal Plants Studies, 13 (2). pp. 8-17. ISSN 2394-0530

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Abstract

Goldenseal (Hydrastis canadensis L.) is a medicinal plant that is commonly used in traditional medicine and as a dietary supplement. This plant's rhizomes/roots have been used to treat a wide range of conditions. Berberine and hydrastine are the most active alkaloids in goldenseal. Goldenseal extract demonstrated several therapeutic benefits, including anti-diabetic, anti-inflammatory, antimicrobial, hypolipidemic, neuroprotective, cardioprotective, and digestive protection. Numerous studies have demonstrated that goldenseal extracts and components have health benefits. This study investigated the anti-diabetic and weight reduction effects of goldenseal root extract in Wistar albino rats. Diabetes was induced by administering streptozotocin intraperitoneally at a dose of 35 mg/kg body weight. The diabetic rats were given goldenseal root extract at various doses (150, 250, 350 and 450 ppm/kg body weight), or none, for 8 weeks. Diabetic groups were compared with a non-diabetic control group. After 8 weeks of application in diabetic rats, the goldenseal root extract was associated with a reduction in feed intake (11%; ***p<0.001) and body weight (15%; ***p<0.001), and significant decreases in random blood glucose (33.2%; **p<0.01), fasting blood glucose (45.6%; ***p<0.001), and glycosylated haemoglobin (HbA1c) (29.5%; ***p<0.001), while insulin (1.15 times; ***p<0.001) and liver glycogen (1.7 times; **p<0.01) levels significantly improved compared to untreated diabetic rats. The study found that goldenseal root extract has anti-diabetic and weight-management properties in Wistar albino rats. Therefore, it appears to be an effective alternative treatment for type 2 Diabetes and weight management.

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