Systems biology of monovalent cation homeostasis in yeast: the translucent contribution

Ariño, Joaquín and Aydar, Ebru and Drulhe, Samuel and Ganser, Daniel and Jorrín, Jesús and Kahm, Matthias and Krause, Falko and Petrezsélyová, Silvia and Yenush, Lynne and Zimmermannová, Olga and van Heusden, G. Paul H. and Kschischo, Maik and Ludwig, Jost and Palmer, Christopher P. and Ramos, José and Sychrová, Hana (2014) Systems biology of monovalent cation homeostasis in yeast: the translucent contribution. Advances in microbial physiology, 64. pp. 1-63. ISSN 0065-2911

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Abstract

Maintenance of monovalent cation homeostasis (mainly K(+) and Na(+)) is vital for cell survival, and cation toxicity is at the basis of a myriad of relevant phenomena, such as salt stress in crops and diverse human diseases. Full understanding of the importance of monovalent cations in the biology of the cell can only be achieved from a systemic perspective. Translucent is a multinational project developed within the context of the SysMO (System Biology of Microorganisms) initiative and focussed in the study of cation homeostasis using the well-known yeast Saccharomyces cerevisiae as a model. The present review summarize how the combination of biochemical, genetic, genomic and computational approaches has boosted our knowledge in this field, providing the basis for a more comprehensive and coherent vision of the role of monovalent cations in the biology of the cell.

Item Type: Article
Uncontrolled Keywords: Cation transport; Potassium homeostasis; Saccharomyces cerevisiae; Salt stress; Systems biology
Subjects: 500 Natural Sciences and Mathemetics > 570 Life sciences; biology
Department: School of Human Sciences
Depositing User: Chris Palmer
Date Deposited: 07 Apr 2016 08:35
Last Modified: 07 Apr 2016 08:35
URI: http://repository.londonmet.ac.uk/id/eprint/966

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