Natural and synthetic homoisoflavonoids and related compounds for the treatment of macular degeneration

Schwikkard, S., Hiles, J., Opara, Elizabeth, Whitmore, H., Corson, T. and Mulholland, D. (2022) Natural and synthetic homoisoflavonoids and related compounds for the treatment of macular degeneration. In: GA – 70th Annual Meeting 2022, 28- 31 August 2022, Thessaloniki, Greece.

Full text not available from this repository. (Request a copy)

Abstract / Description

The inhibition of angiogenesis is a drug target with widespread application. Macular conditions affect around 1.5 million people in the UK, with most of them suffering from age-related macular degeneration. AMD is the biggest cause of sight loss in the UK, affecting about 600 000 people. Wet age-related macular degeneration it is characterized by extensive neovascularisation of the retina. Current treatments include the use of anti-VEGF agents such as Bevacizumab (Avastin) and Ranibizumab (Lucentis). Due to the cost of these treatments and the variable outcomes, the possibility of a small molecule treatment is very attractive. Homoisoflavonoids are C-16 natural products isolated primarily from the Asparagaceae family. These compounds have shown promising activity in vitro and in some initial in vivo analyses. A wide range of homoisoflavonoids, both extracted from natural sources as well as of synthetic origin have been screened for selectivity towards human retinal microvascular endothelial (HREC) cells, as well as being assessed for their ability to inhibit tube formation using a Matrigel assay. The work has highlighted some key structural features that are important for activity and selectivity. Synthetic methodology has been developed and optimised to allow for the production of a range of structurally diverse homoisoflavonoids showing good activity and promise for further development as therapeutic agents.

Item Type:	Conference or Workshop Item (Paper)
Additional Information:	** From Crossref proceedings articles via Jisc Publications Router
Uncontrolled Keywords:	Macular Society UK; macular degeneration; wet age-related macular degeneration; homoisoflavonoids
Subjects:	600 Technology > 610 Medicine & health
Department:	School of Human Sciences
SWORD Depositor:	Pub Router
Depositing User:	Pub Router
Date Deposited:	20 Feb 2023 12:42
Last Modified:	20 Feb 2023 12:42
URI:	https://repository.londonmet.ac.uk/id/eprint/8203

Actions (login required)

View Item