The novel BRDT inhibitor NHWD870 shows potential as a male contraceptive in mice

Wu, Sixian, Li, Xiaoliang, Shang, Lijun, Wu, Lvying, Li, Tongtong, Li, Peiyv, Ji, Zhiliang, Hou, Jianwen, Yin, Mingzhu and Xu, Wenming (2022) The novel BRDT inhibitor NHWD870 shows potential as a male contraceptive in mice. Acta Biochimica et Biophysica Sinica, 54 (10). pp. 1-12. ISSN 1745-7270

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Abstract / Description

Small molecule inhibitors of the bromodomain and extraterminal domain (BET) family proteins have emerged as a promising option for not only the treatment of multiple cancers but also for disturbing the process of sperm maturation with potential for use as a viable contraceptive target. In this paper, we report a new generation of BET family inhibitor, NHWD870, that provide a complete and reversible contraceptive effect in mice which is stronger than that of JQ1 and its synthesized derivatives. This study is hoped to lead to the clinical trial eventually.

Item Type:	Article
Uncontrolled Keywords:	male contraception; NHWD870; BRDT; bromodomain and extraterminal domain (BET) family inhibitor; spermatogenesis
Subjects:	500 Natural Sciences and Mathematics > 570 Life sciences; biology
Department:	School of Human Sciences
Depositing User:	Lijun Shang
Date Deposited:	17 Oct 2022 09:10
Last Modified:	11 Nov 2022 10:06
URI:	https://repository.londonmet.ac.uk/id/eprint/7922

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