Polyphenol-rich tart cherries (Prunus Cerasus, cv Montmorency) improve sustained attention, feelings of alertness and mental fatigue and influence the plasma metabolome in middle-aged adults: a randomised, placebo-controlled trial

Kimble, Rachel, Keane, Karen M., Lodge, John K., Cheung, William, Haskell-Ramsay, Crystal F. and Howatson, Glyn (2022) Polyphenol-rich tart cherries (Prunus Cerasus, cv Montmorency) improve sustained attention, feelings of alertness and mental fatigue and influence the plasma metabolome in middle-aged adults: a randomised, placebo-controlled trial. British Journal of Nutrition. pp. 1-12. ISSN 0007-1145

[img]
Preview
Text
Kimble-2022-Polyphenol-rich-tart-cherries-prunu.pdf - Published Version

Download (1MB) | Preview
Official URL: http://dx.doi.org/10.1017/S0007114522000460

Abstract / Description

Tart Montmorency cherries (MC) are a particularly rich source of anthocyanins and other polyphenols that have been shown to elicit antioxidant,anti-inflammatory and vasomodulatory actions. The current study aimed to determine the influence of chronic MC supplementation on cognitivefunction and mood. In a 3-month double-blinded, placebo-controlled parallel study, middle-aged adults (mean±SD:48±6 years) were ran-domly assigned to either 30 ml twice daily of MC (n25) or the same amount of an isoenergetic placebo (n25). Cognitive function and moodwere assessed before and after supplementation using a computerised cognitive task battery and visual analogue scales. Cerebral blood flow wasalso monitored by near-infrared spectroscopy during the task battery, and questionnaires were administered to determine subjective sleep andhealth status and plasma metabolomics were analysed before and after supplementation. After 3 months, the MC resulted in higher accuracy indigit vigilance (mean difference: 3·3, 95 % CI: 0·2, 6·4 %) with lower number of false alarms (mean difference:−1·2, 95 % CI:−2·0,−0·4) com-pared with the placebo. There was also a treatment effect for higher alertness (mean difference: 5·9, 95 % CI: 1·3, 10·5 %) and lower mentalfatigue ratings (mean difference−9·5, 95 % CI:−16·5,−2·5 %) with MC. Plasma metabolomics revealed an increase in a number of amino acidsin response to MC intake, but not placebo. These data suggest an anti-fatiguing effect of MC supplementation as well as the ability to improvesustained attention during times of high cognitive demand, this could be related to changes in amino acid metabolism

Item Type: Article
Additional Information: All Rights Reserved
Uncontrolled Keywords: Anthocyanins: Cerebral blood flow: Sleep: Sustained attention: Mental fatigue: Bond–Lader: Metabolomics
Subjects: 500 Natural Sciences and Mathematics > 570 Life sciences; biology
Department: School of Human Sciences
Depositing User: John Lodge
Date Deposited: 29 Jul 2022 09:22
Last Modified: 29 Jul 2022 09:22
URI: http://repository.londonmet.ac.uk/id/eprint/7836

Downloads

Downloads per month over past year



Downloads each year

Actions (login required)

View Item View Item