Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH trial

Kempf, Kerstin, Röhling, Martin, Banzer, Winfried, Braumann, Klaus Michael, Halle, Martin, Schaller, Nina, McCarthy, David, Predel, Hans Georg, Schenkenberger, Isabelle, Tan, Susanne, Toplak, Hermann, Martin, Stephan and Berg, Aloys (2022) Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH trial. Nutrients, 14 (12). pp. 1-14. ISSN 2072-6643

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Abstract / Description

Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle intervention alone. In the international, multicentre, randomised-controlled ACOORH-trial (Almased-Concept-against-Overweight-and-Obesity-and-Related- Health-Risk), overweight or obese participants with metabolic syndrome criteria ( = 463) were randomised into two groups and received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement. Data were collected at baseline, after 1, 3, 6, and 12 months. All datasets providing leptin data ( = 427) were included in this predefined subanalysis. Serum leptin levels significantly correlated with sex, body mass index, weight, and fat mass at baseline ( < 0.0001). Stronger leptin reduction has been observed in the intervention compared to the control group with the lowest levels after 1 month of intervention (estimated treatment difference -3.4 µg/L [1.4; 5.4] for females; -2.2 µg/L [1.2; 3.3] for males; < 0.001 each) and was predictive for stronger reduction of body weight and fat mass ( < 0.001 each) over 12 months. Strongest weight loss was observed after 6 months (-5.9 ± 5.1 kg in females of the intervention group vs. -2.9 ± 4.9 kg in the control group ( < 0.0001); -6.8 ± 5.3 kg vs. -4.1 ± 4.4 kg ( = 0.003) in males) and in those participants with combined leptin and insulin decrease. A meal replacement-based lifestyle intervention effectively reduces leptin which is predictive for long-term weight loss.

Item Type:	Article
Additional Information:	** From PubMed via Jisc Publications Router
Uncontrolled Keywords:	low-glycaemic meal replacement; leptin; obesity; hypoglycemia; weight loss; humans; weight reduction; body mass index (BMI); RCT; ACOORH-trial (Almased-Concept-against-Overweight-and-Obesity-and-Related- Health-Risk)
Subjects:	600 Technology > 610 Medicine & health
Department:	School of Human Sciences
SWORD Depositor:	Pub Router
Depositing User:	Pub Router
Date Deposited:	12 Jul 2022 14:15
Last Modified:	12 Jul 2022 14:15
URI:	http://repository.londonmet.ac.uk/id/eprint/7800

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