Structure of the A-DNA Octamer d(GGCATGCC)

Nunn, Christine M. and Neidle, Stephen (1997) Structure of the A-DNA Octamer d(GGCATGCC). Acta Crystallographica Section D Biological Crystallography, 53 (3). pp. 269-273. ISSN 0907-4449

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Official URL: http://dx.doi.org/10.1107/S0907444996014795

Abstract

The crystal structure of the self-complementary DNA octamer d(GGCATGCC) has been determined to a resolution of 2.38 ]k and R factor of 17.1%. The structure is an A-DNA octamer duplex with Watson-Crick base pairing along its length. This sequence extends the investigation of octamer duplexes of the type d(GGXaCC) which assume P61 packing within the crystallographic unit cell. The A-DNA duplex is non-linear with a helix axis curvature of 7 ° and bending towards the DNA minor groove. In view of the biological importance of protein recognition of some A-DNA sequences the minor-groove geometry and helix-axis curvature for this structure is compared with all others of the type d(GGXATXCC).

Item Type: Article
Uncontrolled Keywords: crystal structures, self-complementary DNA octamer d(GGCATGCC), A-DNA octamer duplexes, deoxyribonucleic acid
Subjects: 500 Natural Sciences and Mathemetics > 540 Chemistry & allied sciences
Department: School of Human Sciences
Depositing User: Christine Nunn
Date Deposited: 03 Aug 2015 13:38
Last Modified: 18 Aug 2015 10:46
URI: http://repository.londonmet.ac.uk/id/eprint/746

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