Communication is key: extracellular vesicles as mediators of infection and defence during host-microbe interactions in animals and plants.

Stotz, Henrik U., Brotherton, Dominik and Inal, Jameel (2021) Communication is key: extracellular vesicles as mediators of infection and defence during host-microbe interactions in animals and plants. FEMS microbiology reviews. pp. 1-18. ISSN 1574-6976 (In Press)

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Official URL: https://doi.org/10.1093/femsre/fuab044

Abstract / Description

Extracellular vesicles (EVs) are now understood to be ubiquitous mediators of cellular communication. In this review, we suggest that EVs have evolved into a highly regulated system of communication with complex functions including export of wastes, toxins and nutrients, targeted delivery of immune effectors, and vectors of RNA silencing. Eukaryotic EVs come in different shapes and sizes and have been classified according to their biogenesis and size distributions. Small EVs (sEVs or exosomes) are released through fusion of endosome-derived multivesicular bodies (MVBs) with the plasma membrane. Medium EVs (mEVs or microvesicles) bud off the plasma membrane as a form of exocytosis. Finally, large EVs (lEVs or apoptotic bodies) are produced as a result of the apoptotic process. This review considers EV secretion and uptake in four eukaryotic kingdoms, three of which produce cell walls. The impact cell walls have on EVs in plants and fungi are discussed, as are roles of fungal EVs in virulence. Contributions of plant EVs to development and innate immunity are presented. Compelling cases are sporophytic self-incompatibility and cellular invasion by haustorium-forming filamentous pathogens. The involvement of EVs in all of these eukaryotic processes is reconciled considering their evolutionary history.

Item Type: Article
Uncontrolled Keywords: biotroph; cellular cross-kingdom communication; endophytic; ESCRT; oomycete; pathogenesis
Subjects: 500 Natural Sciences and Mathematics > 570 Life sciences; biology
Department: School of Human Sciences
Depositing User: Jameel Inal
Date Deposited: 13 Sep 2021 08:40
Last Modified: 13 Sep 2021 08:40
URI: http://repository.londonmet.ac.uk/id/eprint/6972

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