Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1

McLean, Gary R. and Walton, Ross P. and Shetty, Shweta and Peel, Tamlyn J. and Paktiawal, Nasren and Kebadze, Tatiana and Gogsadze, Leila and Niespodziana, Katarzyna and Valenta, Rudolf and Bartlett, Nathan W. and Johnston, Sebastian L. (2012) Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1. Antiviral research, 95 (3). pp. 193-201. ISSN 1872-9096

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Abstract

Rhinoviruses (RVs) are ubiquitous human respiratory viruses, the major cause of common colds, acute exacerbations of asthma and other respiratory diseases. The development of antibodies to RV following primary infection is poorly understood and there is currently no RV vaccine available. We therefore used mouse models of intranasal RV infection and immunisation to determine the induction, magnitude and specificity of antibody responses. Strong cross-serotype RV-specific IgG responses in serum and bronchoalveolar lavage were induced towards the RV capsid protein VP1. IgA responses were weaker, requiring two infections to generate detectable RV-specific binding. Similarly two or more RV infections were necessary to induce neutralising antibodies. Immunisation strategies boosted homotypic as well as inducing cross-serotype neutralising IgG responses. We conclude that VP1 based antigens combined with adjuvants may permit successful antibody-mediated vaccine design and development.

Item Type: Article
Uncontrolled Keywords: antibodies, rhinovirus (RV), vaccines, mouse model
Subjects: 600 Technology > 610 Medicine & health
Department: School of Human Sciences
Depositing User: Gary Mclean
Date Deposited: 17 Jul 2015 08:20
Last Modified: 17 Jul 2015 08:20
URI: http://repository.londonmet.ac.uk/id/eprint/656

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