Identification of similar epitopes between SARS-CoV-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity

Urbán, Szabolcs, Paragi, Gábor, Burián, Katalin, McLean, Gary R. and Virok, Dezső P. (2020) Identification of similar epitopes between SARS-CoV-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity. Clinical & Translational Immunology, 9 (12). pp. 1-8. ISSN 2050-0068

Abstract

Objectives:
Bacillus Calmette–Guérin (BCG) vaccination has been implicated in protection against SARS-CoV-2 and as a non-specific immunization method against the virus. We therefore decided to investigate T cell and B cell epitopes within the BCG Pasteur strain proteome for similarity to immunogenic peptides of SARS-CoV-2.

Methods:
We used a bioinformatic approach and analyzed the BCG-Pasteur proteome to identify similar peptides to established and novel SARS-CoV-2 T cell and B cell epitopes.

Results:
We found 112 BCG MHC-I restricted T cell epitopes similar to MHC-I restricted T cell SARS-CoV-2 epitopes and 690 BCG B cell epitopes similar to SARS-CoV-2 B cell epitopes. The SARS-CoV-2 T cell epitopes represented 16 SARS-CoV-2 proteins, the SARS-CoV-2 B cell epitopes represented 5 SARS-CoV-2 proteins, including the receptor binding domain of the spike glycoprotein.

Conclusion:
Altogether our results provide a mechanistic basis for the potential cross-reactive adaptive immunity that may exists between the two microorganisms.

Documents
6221:33222
[img]
Preview
Manuscript_full-revised-161120.pdf - Accepted Version
Available under License Creative Commons Attribution 4.0.

Download (781kB) | Preview
6221:33228
[img]
Preview
cti2.1227.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0.

Download (1MB) | Preview
Details
Record
Statistics

Downloads

Downloads per month over past year



Downloads each year

View Item View Item