The use of genotoxicity biomarkers in molecular epidemiology: applications in environmental, occupational and dietary studies

Ladeira, Carina and Smajdova, Lenka (2017) The use of genotoxicity biomarkers in molecular epidemiology: applications in environmental, occupational and dietary studies. AIMS genetics, 4 (3). pp. 166-191. ISSN 2377-1143

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Abstract / Description

Molecular epidemiology is an approach increasingly used in the establishment of associations between exposure to hazardous substances and development of disease, including the possible modulation by genetic susceptibility factors. Environmental chemicals and contaminants from anthropogenic pollution of air, water and soil, but also originating specifically in occupational contexts, are potential sources of risk of development of disease. Also, diet presents an important role in this process, with some well characterized associations existing between nutrition and some types of cancer. Genotoxicity biomarkers allow the detection of early effects that result from the interaction between the individual and the environment; they are therefore important tools in cancer epidemiology and are extensively used in human biomonitoring studies. This work intends to give an overview of the potential for genotoxic effects assessment, specifically with the cytokinesis blocked micronucleus assay and comet assay in environmental and occupational scenarios, including diet. The plasticity of these techniques allows their inclusion in human biomonitoring studies, adding important information with the ultimate aim of disease prevention, in particular cancer, and so it is important that they be included as genotoxicity assays in molecular epidemiology.

Item Type: Article
Additional Information: ** From Europe PMC via Jisc Publications Router
Uncontrolled Keywords: molecular epidemiology; biomarkers; genotoxicity; micronuclei; comet assay; environment; occupation; diet
Subjects: 300 Social sciences > 360 Social problems & services; associations
500 Natural Sciences and Mathematics > 570 Life sciences; biology
600 Technology > 610 Medicine & health
Department: School of Social Sciences (to June 2021)
School of Social Sciences and Professions
SWORD Depositor: Pub Router
Depositing User: Pub Router
Date Deposited: 16 Oct 2019 10:36
Last Modified: 16 Oct 2019 10:36


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