Vaccine strategies to induce broadly protective immunity to rhinoviruses

McLean, Gary R. (2019) Vaccine strategies to induce broadly protective immunity to rhinoviruses. Human vaccines & immunotherapeutics, 16 (3). pp. 684-686. ISSN 2164-5515

McLean commentary 070819.pdf - Accepted Version

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Abstract / Description

Rhinoviruses are ubiquitous human pathogens of the upper respiratory tract and are the major cause of acute exacerbations of asthma and chronic obstructive pulmonary disease. At least 160 antigenically distinct serotypes or strains have been identified and protective immunity is largely serotype specific. Attempts to produce vaccines that induce broad immunity have met with limited success which is due in part to this antigenic diversity and a lack of information regarding the ideal protective immune responses. Recent approaches identifying conserved rhinovirus epitopes and better definitions of the immune correlates of protection have raised hope. Here, these newer findings are outlined and the prospects for such a universal rhinovirus vaccine are discussed.

Item Type: Article
Uncontrolled Keywords: rhinoviruses, vaccine, neutralising antibodies, epitopes
Subjects: 500 Natural Sciences and Mathematics > 570 Life sciences; biology
600 Technology > 610 Medicine & health
Department: School of Social Sciences (to June 2021)
School of Social Sciences and Professions
Depositing User: Gary Mclean
Date Deposited: 09 Sep 2019 09:56
Last Modified: 12 Mar 2021 11:54


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