Novel epidithiodiketopiperazines as anti-viral zinc ejectors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein as a model for HIV infection

Asquith, Christopher R. M., Sil dos Santos, Bruno, Laitinen, Tuomo, Tizzard, Graham J., Coles, Simon J., Poso, Antti, Hofmann-Lehmann, Regina and Hilton, Stephen T. (2019) Novel epidithiodiketopiperazines as anti-viral zinc ejectors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein as a model for HIV infection. Bioorganic & Medicinal Chemistry. ISSN 0968-0896

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Abstract / Description

Focused libraries of multi-substituted epidithiodiketopiperazines (ETP) were prepared and evaluated for efficacy of inhibiting the nucleocapsid protein function of the Feline Immunodeficiency Virus (FIV) as a model for HIV. This activity was compared and contrasted to observed toxicity utilizing an in-vitro cell culture approach. This resulted in the identification of several promising lead compounds with nanomolar potency in cells with low toxicity and a promising therapeutic index.

Item Type: Article
Additional Information: ** From Elsevier via Jisc Publications Router ** History: accepted 28-07-2019; ** Licence for AM version of this article: This article is under embargo with an end date yet to be finalised.
Subjects: 500 Natural Sciences and Mathematics > 570 Life sciences; biology
Department: School of Human Sciences
SWORD Depositor: Pub Router
Depositing User: Pub Router
Date Deposited: 09 Aug 2019 12:00
Last Modified: 09 Aug 2019 12:00
URI: http://repository.londonmet.ac.uk/id/eprint/5033

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