Increased central adiposity may not underlie the marked elevation of IL-6 in Diabetes Mellitus patients in South-West Nigeria

Oghagbon, Efosa K., Jimoh, Kazeem A., Olaosebikan, Olabode and Harbige, Laurence S. (2014) Increased central adiposity may not underlie the marked elevation of IL-6 in Diabetes Mellitus patients in South-West Nigeria. West African Journal of Medicine, 33 (2). pp. 130-135. ISSN 0189-160X

[img]
Preview
Text
WAJM 33(2) 2014 Increased Central Adiposity may not Underlie the Marked Elevation of IL-6 in Diabetes .pdf - Published Version

Download (105kB) | Preview
Official URL: https://www.ajol.info/index.php/wajm/index

Abstract / Description

Background:
Chronic inflammation is linked to disorders of obesity, insulin resistance and DM2. This reflects as increase in proinflammatory cytokines including IL-6. In Nigeria, there is no study that has measured IL-6 in diabetics, in spite of having the highest number of diabetics in Africa.

Methods:
The twenty-eight DM2 patients and 13 controls recruited for this study had their BP, BMI, waist circumference (WC) and waist-hip-ratio (WHR) measured. They also had fasting plasma IL-6, fasting plasma glucose, total cholesterol (TC), Triglyceride (Tg), high density lipoprotein cholesterol (HDL-C), urea, creatinine, aspartate transaminases (AST), alanine transferases (ALT), total protein (TP) and albumin determined.

Results:
Mean age was 51.83 years ± 13.28, with diabetics significantly older than controls (56.61yrs. ±9.62 vs. 41.54 years ± 14.53) P < 0.05. The mean IL-6 in diabetics (194.77pg/ml ± 166.16) was significantly higher than controls’ (26.29pg/ml ± 6.65) at p < 0.01. No significant difference in mean BMI in diabetics and controls. But WC and WHR of diabetics (100.75cm ± 18.47; 1.01 ± 0.14) were significant higher than in controls (88.77cm ± 13.36; 0.88 ± 0.07) at p < 0.05 (WC; p value 0.043) and p < 0.01(WHR; p value 0.002). Among diabetics, there were significant correlations between IL-6 and Tg (p<0.01, r = 0.007**), IL-6 and LDL-C (p<0.05, r = 0.028*), IL-6 and AST (p<0.05, r = 0.041*) and IL-6 and ALT (p<0.01, r = 0.004**)

Conclusion:
Elevated IL-6 in DM2 patients in South West Nigeria correlates with liver transaminases and not increased markers of central adiposity.

Item Type: Article
Uncontrolled Keywords: Diabetes Mellitus; South-West Nigeria; obesity; insulin resistance; diabetics
Subjects: 600 Technology > 610 Medicine & health
Department: School of Human Sciences
Depositing User: Laurence Harbige
Date Deposited: 08 Nov 2018 15:18
Last Modified: 08 Nov 2018 15:18
URI: http://repository.londonmet.ac.uk/id/eprint/3765

Actions (login required)

View Item View Item