The synthesis and pharmacology of some novel excitatory amino acid analogues

Badman, G. T. (1986) The synthesis and pharmacology of some novel excitatory amino acid analogues. Doctoral thesis, City of London Polytechnic.

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Abstract / Description

Certain amino acids, notably L-glutamate and L-aspartate, are believed to fulfil a role as excitatory neurotransmitters in the mammalian Central Nervous System (CNS). Investigation has revealed the presence of three, and possibly a fourth, type of receptor for such neurotransmitters. These receptors have been named after the most potent and selective agonist of each; thus they are usually referred to as N-methyl-D-aspartate (A1), quisqualate (A2), kainate (A3) and 2-amino, 4-phosphono butyric acid (A4); the designations in brackets being that of the nomenclature of Fagg and Foster.

Item Type: Thesis (Doctoral)
Additional Information: uk.bl.ethos.372742
Uncontrolled Keywords: Pharmaceutical chemistry; Pharmacology; Amino acids
Subjects: 500 Natural Sciences and Mathematics > 540 Chemistry & allied sciences
600 Technology > 610 Medicine & health
Department: School of Human Sciences
Depositing User: Mary Burslem
Date Deposited: 20 Sep 2018 14:17
Last Modified: 20 Sep 2018 14:17
URI: http://repository.londonmet.ac.uk/id/eprint/3278

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