The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics

Okonkwo, P. I. (1992) The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics. Doctoral thesis, London Guildhall University.

Preview

Text 238892.pdf - Published Version Download (10MB) | Preview

Abstract / Description

L-Glutamic acid and L-aspartic acid are believed to be the principal initiators of excitatory synaptic neurotransmission in the mammalian central system. A number of molecules of either natural or synthetic origin have been identified as possessing agonist or antagonist properties at glutamate binding sites. One of the most potent agonist is quisqualic acid (69), and this thesis features two aspects of the synthetic organic chemistry and the pharmacology of quisqualic acid and some of its analogues.

Item Type:	Thesis (Doctoral)
Additional Information:	uk.bl.ethos.238892
Uncontrolled Keywords:	Neurotransmitters; Neurochemistry
Subjects:	500 Natural Sciences and Mathematics 500 Natural Sciences and Mathematics > 540 Chemistry & allied sciences
Department:	School of Human Sciences
Depositing User:	Maria White
Date Deposited:	29 Aug 2018 15:28
Last Modified:	29 Aug 2018 15:33
URI:	https://repository.londonmet.ac.uk/id/eprint/2965

Downloads

Actions (login required)

View Item