Human cytomegalovirus vaccination: progress and perspectives of recombinant gB

Manghera, Avneet and McLean, Gary R. (2016) Human cytomegalovirus vaccination: progress and perspectives of recombinant gB. Future Virology. ISSN 1746-0794

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Abstract

A vaccine for Human cytomegalovirus (HCMV) remains a high priority as complications following infection are observed in immunocompromised individuals and in congenitally infected neonates. Numerous preclinical and clinical studies have investigated vaccine strategies ranging from live attenuated preparations, nucleic acid-based approaches and recombinant delivery systems to subunit vaccines. These have defined the importance of both cell-mediated and humoral immunity to viral gB in the control of HCMV infection. This review will cover clinical trials investigating vaccine approaches that have incorporated gB and discuss the future perspectives of the recombinant gB subunit vaccine for HCMV.

Item Type: Article
Uncontrolled Keywords: clinical trials; Human cytomegalovirus; recombinant gB; vaccine
Subjects: 500 Natural Sciences and Mathemetics > 570 Life sciences; biology
Department: School of Human Sciences
Depositing User: Gary Mclean
Date Deposited: 10 Oct 2017 08:48
Last Modified: 10 Oct 2017 08:48
URI: http://repository.londonmet.ac.uk/id/eprint/1240

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